The Effect of Aerobic Training with and without Elastic Pressure on Complete Blood Count in Obese Males with Deep Vein Thrombosis

Hasanzadeh Fard, Seyyed Majid; Behpour, Nasser; Roozbahani, Mehdi

doi:10.18502/ijdo.v14i4.11227

Volume 14, Issue 4 (11-2022) IJDO 2022, 14(4): 202-209 | Back to browse issues page

‎ 10.18502/ijdo.v14i4.11227

Mendeley

Zotero

RefWorks

Hasanzadeh Fard S M, Behpour N, Roozbahani M. The Effect of Aerobic Training with and without Elastic Pressure on Complete Blood Count in Obese Males with Deep Vein Thrombosis. IJDO 2022; 14 (4) :202-209
URL: http://ijdo.ssu.ac.ir/article-1-745-en.html

The Effect of Aerobic Training with and without Elastic Pressure on Complete Blood Count in Obese Males with Deep Vein Thrombosis

Seyyed Majid Hasanzadeh Fard

, Nasser Behpour ^*

, Mehdi Roozbahani

Associate Professor of Exercise Physiology, Faculty of Sports Sciences, Razi University, Kermanshah, Iran.

Abstract: (714 Views)

Objective: Standard compression stockings are used to create elastic pressure in correcting and maintaining the hemodynamics of deep vein thrombosis (DVT) and prevent limb swelling in patients with DVT. This study aimed to compare the effect of aerobic exercise with lower extremity elastic pressure on some hematological features of obese patients with DVT.
Materials and Methods: For this purpose, 33 obese men (30≤BMI≤36) with DVT were randomly divided into three groups: 1) aerobic exercise with elastic pressure, 2) aerobic exercise without elastic pressure, 3) control group. Interventions were performed for 8 weeks of running in 55-70% of heart rate reserve. To create elastic pressure, elastic socks were used during exercise. Fasting blood samples were taken before and 48 hours after the last training session to compare red blood cells (RBC), hemoglobin, hematocrit, platelets, and white blood cells (WBC) between the groups. ANOVA statistical test and Bonferroni post hoc test were used to compare data.
Results: Although aerobic exercise alone did not lead to changes in variables (P> 0.05), aerobic exercise with elastic pressure reduced RBC (P: 0.001), hemoglobin (P: 0.001), hematocrit (P: 0.001) and platelets (P: 0.001). But changes in WBC were not significant (P: 0.192).
Conclusion: Aerobic exercises with elastic pressure on the lower limb muscles play an important role in re-balancing homeostasis. The erythrocyte systems changes of peripheral blood and reducing hematological factors and reduces hematological parameters in people with DVT are the main factor.

Keywords: Aerobic exercise, Elastic pressure, Deep vein thrombosis, Hematological parameters

Full-Text [PDF 231 kb] (304 Downloads)

Type of Study: Research | Subject: Special
Received: 2022/07/15 | Accepted: 2022/10/2 | Published: 2022/11/19

References

1. Asnaashari A M, Ghobadi Moralou H, Mohamadzadeh Lari S, Ghalenoei E. Obesity hypoventilation syndrome (OHS) and extreme lower limbs deep vein thrombosis (DVT) with heparin induced thrombocytopenia (HIT) and warfarin related cutaneous necrosis. Journal of Ardabil University of Medical Sciences. 2010;10(3):270-6.(in Persian)

2. Terra MF, Pedrosa DG, Zoppi CC, Werneck CC, Vicente CP. Physical exercises decreases thrombus and neointima formation in atherosclerotic mice. Thrombosis research. 2019;175:21-31. [DOI:10.1016/j.thromres.2019.01.003]

3. Evensen LH, Isaksen T, Hindberg K, Brækkan SK, Hansen JB. Repeated assessments of physical activity and risk of incident venous thromboembolism. Journal of Thrombosis and Haemostasis. 2018;16(11):2208-17. [DOI:10.1111/jth.14287]

4. Kearon C, Ageno W, Cannegieter SC, Cosmi B, Geersing GJ, Kyrle PA. Categorization of patients as having provoked or unprovoked venous thromboembolism: guidance from the SSC of ISTH. Journal of thrombosis and haemostasis: JTH. 2016;14(7):1480-3. [DOI:10.1111/jth.13336]

5. Kim L, Lim Y, Park SY, Kim YJ, Kwon O, Lee JH, et al. A comparative study of the antithrombotic effect through activated endothelium of garlic powder and tomato extracts using a rodent model of collagen and epinephrine induced thrombosis. Food science and biotechnology. 2018;27(5):1513-8. [DOI:10.1007/s10068-018-0469-z]

6. Menon H, Pillai A, Aussenberg-Rodriguez J, Ambrose J, Youssef I, Griffiths EG, et al. Cost reduction associated with heparin-induced thrombocytopenia panel ordering for enoxaparin versus heparin for prophylactic and therapeutic use: A retrospective analysis in a community hospital setting. Avicenna journal of medicine. 2018;8(04):133-8. [DOI:10.4103/ajm.AJM_78_18]

7. Andrews DA, Low PS. Role of red blood cells in thrombosis. Current opinion in hematology. 1999;6(2):76. [DOI:10.1097/00062752-199903000-00004]

8. Litvinov RI, Weisel JW. Role of red blood cells in haemostasis and thrombosis. ISBT science series. 2017;12(1):176-83. [DOI:10.1111/voxs.12331]

9. Ahmadizad S, Malekian E, Khani E, Rahmani H. Exercise and Training Effects on Platelet Activation and Function: A Review Article. Journal of Sport Physiology. 2019;11(43):17-38.(in Persian)

10. Mairbäurl H. Red blood cells in sports: effects of exercise and training on oxygen supply by red blood cells. Frontiers in physiology. 2013;4:332. [DOI:10.3389/fphys.2013.00332]

11. Natale VM, Brenner IK, Moldoveanu AI, Vasiliou P, Shek P, Shephard RJ. Effects of three different types of exercise on blood leukocyte count during and following exercise. Sao Paulo Medical Journal. 2003;121:09-14. [DOI:10.1590/S1516-31802003000100003]

12. Mousavizadeh, M.S., Ebrahim, K.h., Nikbakht, HA. Effect of one period of selective aerobic training on hematological indexes of girls. The Scientific Journal of Iranian Blood Transfusion Organization. 2009;6(3):227-31.(in Persian)

13. Amini A, Kordi MR, Gaini AA, Ahmadi A, Ayoubian H, Lahoorpour F. The effects of aerobic exercises on coagulation and fibrinolytic factors in inactive aged men. Scientific Journal of Kurdistan University of Medical Sciences. 2011;15(4):25-32.(in Persian)

14. El-Menyar A, Asim M, Al-Thani H. Obesity paradox in patients with deep venous thrombosis. Clinical and Applied Thrombosis/Hemostasis. 2018;24(6):986-92. [DOI:10.1177/1076029617727858]

15. Klovaite J, Benn M, Nordestgaard BG. Obesity as a causal risk factor for deep venous thrombosis: a M endelian randomization study. Journal of internal medicine. 2015;277(5):573-84. [DOI:10.1111/joim.12299]

16. Kahn SR, Elman E, Rodger MA, Wells PS. Use of elastic compression stockings after deep venous thrombosis: a comparison of practices and perceptions of thrombosis physicians and patients 1. Journal of Thrombosis and Haemostasis. 20031(3):500-6. [DOI:10.1046/j.1538-7836.2003.00098.x]

17. Roche-Nagle G, Ward F, Barry M. Current prescribing patterns of elastic compression stockings post-deep venous thrombosis. Phlebology. 2010;25(2):72-8. [DOI:10.1258/phleb.2009.009002]

18. Rimaud D, Calmels P, Roche F, Mongold JJ, Trudeau F, Devillard X. Effects of graduated compression stockings on cardiovascular and metabolic responses to exercise and exercise recovery in persons with spinal cord injury. Archives of physical medicine and rehabilitation. 2007;88(6):703-9. [DOI:10.1016/j.apmr.2007.03.023]

19. Mayberry JC, Moneta GL, De Frang RD, Porter JM. The influence of elastic compression stockings on deep venous hemodynamics. Journal of vascular surgery. 1991;13(1):91-100. https://doi.org/10.1016/0741-5214(91)90016-N [DOI:10.1067/mva.1991.25386]

20. Hirai M, Iwata H, Hayakawa N. Effect of elastic compression stockings in patients with varicose veins and healthy controls measured by strain gauge plethysmography. Skin research and technology. 2002;8(4):236-9. [DOI:10.1034/j.1600-0846.2001.80401.x]

21. Sioson E, Alexander JJ, Mentari A, Heitz R, Mion L. Effect of elastic compression stockings on venous hemodynamics in hemiplegic patients. Journal of Stroke and Cerebrovascular Diseases. 1992;2(4):196-201. [DOI:10.1016/S1052-3057(10)80045-X]

22. Ibegbuna V, Delis KT, Nicolaides AN, Aina O. Effect of elastic compression stockings on venous hemodynamics during walking. Journal of vascular surgery. 2003;37(2):420-5. [DOI:10.1067/mva.2003.104]

23. Asadi MB, Sharifi H, Abedi B, Fatolahi H. Acute inflammatory response to a single bout of resistance exercise with or without blood flow restriction. International Journal of Sport Studies for Health. 2020;3(2):e110594. [DOI:10.5812/intjssh.110594]

24. Abe T, Kearns CF, Sato YJ. Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training. Journal of Applied Physiology (1985). 2006; 100(5):1460-6. [DOI:10.1152/japplphysiol.01267.2005]

25. Evensen LH, Braekkan SK, Hansen JB. Regular physical activity and risk of venous thromboembolism. InSeminars in thrombosis and hemostasis 2018;44(8):765-9. [DOI:10.1055/s-0038-1673636]

26. Rajabi H, Khedmatgozar E, Dastmalchi J, Dehkhoda M. Comparison of high-intensity interval and continuous training effects on plasma levels of fibrinolytic factors in CAD patients. Jundishapur Scientific Medical Journal. 2019;18(3):287-300.(in Persian)

27. Kishimoto S, Maruhashi T, Kajikawa M, Matsui S, Hashimoto H, Takaeko Y, et al. Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men. Scientific reports. 2020;10(1):1-9. [DOI:10.1038/s41598-020-68319-1]

28. Shapoorabadi YJ, Vahdatpour B, Salesi M, Ramezanian H. Effects of aerobic exercise on hematologic indices of women with rheumatoid arthritis: A randomized clinical trial. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. 2016;21(1):9. [DOI:10.4103/1735-1995.177356]

29. Pourghardash F, Nikseresht A. Investigating the effect of regular aerobic activity on young females hematology. IIOABJ Journal. 2017;8(1):39-45.

30. Patelis N, Karaolanis G, Kouvelos GN, Hart C, Metheiken S. The effect of exercise on coagulation and fibrinolysis factors in patients with peripheral arterial disease. Experimental Biology and Medicine. 2016;241(15):1699-707. [DOI:10.1177/1535370216660215]

31. Gram AS, Bladbjerg EM, Skov J, Ploug T, Sjödin A, Rosenkilde M, et al. Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men. European journal of applied physiology. 2015;115(6):1331-8. [DOI:10.1007/s00421-015-3106-z]

32. Lamprecht M, Moussalli H, Ledinski G, Leschnik B, Schlagenhauf A, Koestenberger M, et al. Effects of a single bout of walking exercise on blood coagulation parameters in obese women. Journal of applied physiology. 2013;115(1):57-63. [DOI:10.1152/japplphysiol.00187.2013]

33. Sandrini L, Ieraci A, Amadio P, Zarà M, Mitro N, Lee FS, et al. Physical exercise affects adipose tissue profile and prevents arterial thrombosis in BDNF Val66Met mice. Cells. 2019;8(8):875. [DOI:10.3390/cells8080875]

34. Carlson GP. Thermoregulation and fluid balance in the exercising horse. Equine exercise physiology. 1983;1:291-309.

35. Byrnes JR, Wolberg AS. Red blood cells in thrombosis. Blood, The Journal of the American Society of Hematology. 2017;130(16):1795-9. [DOI:10.1182/blood-2017-03-745349]

36. Hilberg T, Nowacki PE, Müller-Berghaus G, Gabriel HH. Changes in blood coagulation and fibrinolysis associated with maximal exercise and physical conditioning in women taking low dose oral contraceptives. Journal of Science and Medicine in Sport. 2000;3(4):383-90. [DOI:10.1016/S1440-2440(00)80005-5]